類題 大問I 腸内細菌と回復力
- 3つの英文は,すべてTMPS医学館のオリジナルです(人物・大学・団体・数値は架空)。本番の英文より短く作ってあります。
- 選択肢は番号(1〜4)で答える。語数・行数の指定がある問題は,指定を守ること。
Read the following passage and answer the questions that follow.
Researchers at Halden University and the Fenwick Institute for Digestive Science say they have built a "resilience score" from a single stool sample. It may be a better guide to how quickly you will recover from an infection than your age, your weight, or how many vegetables you say you eat. "Two people can catch the same cold and have very different weeks," said Dr. Mara Olsen, the study's lead author. "Our gut bacteria seem to explain part of that gap."
The gut is home to trillions of microbes. In a healthy person, they help digest food, train the immune system, and crowd out harmful species. When this community loses its variety, the balance can tip. A narrow, unstable microbiome ( A ) the risk of long infections, allergies, and digestive disease. Until now, however, no everyday test could measure that instability.
The Halden team recruited 2,400 adults between 2015 and 2020. Their samples were ( B ) a panel of 60 bacterial species, and the volunteers reported every illness they had during the following year.
A machine-learning method then boiled all this data down to a single ( C ) that the team named the resilience score. Higher numbers meant a more varied and stable microbial community. Volunteers in the top fifth of scores recovered from respiratory infections three days faster, on average, than those in the bottom fifth.
To check that the score meant something, the team tried three tests. First, they followed 180 volunteers aged 70 or older for two years and found that a low score at the start predicted more hospital visits. Next, they examined samples from a rural village in northern Spain where many residents live past 90; the villagers' scores were, on average, equal to those of people thirty years younger. Finally, they turned to the Linden Health Study, a separate group of 5,000 adults whose samples had been stored but whose illnesses were never recorded. Their scores ( D ) significantly with the number of sick days the volunteers had taken from work.
Diet has long been ( E ) as the main driver of gut health, and the new study agrees in part: a fibre-rich diet raised scores. But one habit mattered more than any food. People who went to bed within an hour of the same time each night had scores about 12 percent higher than people with irregular sleep, even when they ate similar meals.
Olsen cautions that the score is not yet ready for the clinic. All 2,400 original volunteers were healthy city dwellers, and the score has not been tested in children or in people with chronic disease. "We want a doctor to use this the way she uses blood pressure," Olsen said. "We aren't there yet, but a simple test that shows who needs extra care early would be a real step forward."
問1 Choose the best word from the list to fill in blanks ( A )〜( E ) and write the number in the space on the answer sheet.
(A)
1. repeats2. declines3. cures4. raises
(B)
1. hosted2. screened3. equalized4. avoided
(C)
1. measure2. distance3. tradition4. shortage
(D)
1. consulted2. accounted3. correlated4. persuaded
(E)
1. reflected2. regarded3. confused4. refused
問2 Why did the researchers build the resilience score?
1. To find out why diets differ among cultures.2. To show that age does not affect infections.3. To measure how well a person's gut community may help recovery from illness.4. To identify the single bacterium that causes colds.
問3 What is the resilience score?
1. A count of the bacterial species in a village.2. A single number that sums up how varied and stable a person's gut microbes are.3. A record of how many illnesses a person has had.4. A list of foods that improve gut health.
問4 How did the team check that the score was meaningful?
1. They showed that older volunteers had higher scores than younger volunteers.2. They asked volunteers to rate their own health each year.3. They repeated the same test on the same samples ten times.4. They compared scores with later hospital visits, with long-lived villagers, and with sick leave in another group.
問5 What did the study find about sleep?
1. Regular bedtimes were linked to higher scores, even when meals were similar.2. Sleeping longer matters more than going to bed at a regular time.3. Diet matters less than the number of hours slept.4. Irregular sleepers ate more fibre.